Shelf life (days): 1460
Info: A Bcl-xL inhibitor (Ki = 0.8 nM); selective for Bcl-xL over Bcl-2 (Ki = 67 nM); decreases the proliferation of NCI H146, MOLT-4, and CCRF CEM cells in serum-free media (IC50s = 0.35, 0.74, and 0.21 µM, respectively); reduces tumor growth at 100 mg/kg per day in combination with paclitaxel in an A549 lung cancer mouse xenograft model
Formulation: A solid
Formal Name: N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-4-(4,4-dimethyl-1-piperidinyl)-benzamide
Purity: ≥95%
Formula Markup: C32H41N5O5S2
Formula Weight: 639.83
CAS Number: 406228-55-5