Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-[[5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl]methyl]-pyridine, monohydrochloride
Purity: ≥98%
Formula Markup: C13H9Cl2N5 / HCl
Formula Weight: 342.6
CAS Number: 899431-18-6
Notes: A-438079 is a competitive antagonist of the nucleotide receptor P2X7 (pIC50 = 6.9).{22914} It inhibits both calcium flux and IL-1β release mediated by P2X7 while not affecting the activity of other P2X receptors.{22914,22913} A-438079 is effective in evaluating the role of P2X7 in nociception, oxidative stress, and apoptosis in cells and animals.{22915,22916,22917}