Product Description: A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM.
Applications: Cancer-Kinase/protease
Formula: C22H23ClN4O
Citations: Aging. 2020 Nov 17;12(22):23114-23128./Cell Signal. 2023 Jun 9;109:110753./J Proteome Res. 2018 Oct 5;17(10):3360-3369./Oncotarget. 2016 May 17;7(20):29131-42.
References: [1]Luo Y, et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther, 2005, 4(6), 977-986./[2]Zhu QS, et al. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer Res, 2008, 68(8), 2895-2903./[3]Zou Y, et al. Pre-clinical assessment of A-674563 as an anti-melanoma agent. Biochem Biophys Res Commun. 2016 Aug 12;477(1):1-8./[4]Xu L, et al. Concurrent targeting Akt and sphingosine kinase 1 by A-674563 in acute myeloid leukemia cells. Biochem Biophys Res Commun. 2016 Apr 15;472(4):662-8.
CAS Number: 2070009-66-2
Molecular Weight: 394.90
Compound Purity: 99.86
Research Area: Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic)/H2O : 100 mg/mL (ultrasonic)
Target: Akt
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