Product Description: A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM.
Applications: Cancer-Kinase/protease
Formula: C20H12N2O3S
References: [1]Cool B, et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab, 2006, 3(6), 403-416./[2]Sanders MJ, et al. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J Biol Chem, 2007, 282(45), 32539-32548./[3]Moreno D, et al, A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism. FEBS Lett, 2008, 583(17), 2650-2654./[4]Yerra VG, et al. Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis, Autophagy and Neuroinflammation. Mol Neurobiol. 2017 Apr;54(3):2301-2312.
CAS Number: 844499-71-4
Molecular Weight: 360.39
Compound Purity: 99.20
Research Area: Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 80°C)
Target: AMPK
Deutsch
English
