Product Description: A-770041 is a selective and orally active Src-family Lck inhibitor. A-770041 inhibits Lck with an IC50 value of 147 nM with the presence of 1 mM ATP. A-770041 shows 300-fold selective to Lck over Fyn, the other Src family kinase involved in T-cell signaling. A-770041 can be used for the research of acute rejection[1][2].
Applications: COVID-19-immunoregulation
Formula: C34H39N9O3
References: [1]Stachlewitz RF, et al.A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection.J Pharmacol Exp Ther. 2005 Oct;315(1):36-41./[2]Andrew Burchat, et al. Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection Bioorganic & Medicinal Chemistry Letters Volume 16, Issue 1, 1 January 2006, Pages 118-122
CAS Number: 869748-10-7
Molecular Weight: 621.73
Compound Purity: 99.95
Research Area: Inflammation/Immunology
Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 80°C)
Target: Src
Deutsch
English
