Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2R-[[4’-[[(phenylamino)carbonyl]amino][1R,1’-biphenyl]-4-yl-carbonyl]-cyclopentanecarboxylic acid
Purity: ≥95%
Formula Markup: C26H24N2O4
Formula Weight: 428.5
CAS Number: 959122-11-3
Notes: Diacylglycerol acyltransferases (DGATs) catalyze the final step in triglyceride synthesis. DGAT-1 deficient mice demonstrate a phenotype that is protective against the development of diet-induced obesity (DIO) or insulin resistance, implicating the actions of this enzyme in the development of such metabolic disorders. A-922500 is a potent orally active inhibitor of DGAT-1 activity, inhibiting both human and mouse forms of the enzymes with IC50 values of 7 and 24 nM, respectively.{15816} When administered at 3 mg/kg to DIO mice, A-922500 conferred significant weight loss within seven days without affecting food intake and significantly reduced plasma and liver triglycerides with chronic dosing.{15816} A-922500 does not inhibit DGAT-2, ACAT-1, or ACAT-2.{15816}
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