Shelf life (days): 1460.0
Formulation: A crystalline solid
Purity: ≥90%
Formula Markup: C39H54N10O14S
Formula Weight: 919.0
CAS Number: 23109-05-9
Notes: α-Amanitin is a cyclic peptide found in several species of the Amanita genus as well as other poisonous fungi.{29206} At 1, 10, and 50 µg/ml, respectively, α-amanitin inhibits RNA polymerase II, III, and IV, preventing translocation of the enzymes on DNA, which significantly slows the rate of transcription.{29205,20588} RNA polymerase I is insensitive to its effects. This toxin is used in molecular biology to distinguish among types of RNA polymerase in a sample and to arrest RNA synthesis in transcription studies.{29205}