Product Description: α-Androstenol (5α-Androst-16-en-3α-ol) is a steroid pheromone that has been found in boar testes and human male axillary sweat. α-Androstenol is also a positive modulator of GABAA receptors, which enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50=0.4 μM). α-Androstenol decreases immobility time in the forced swim test and increases time spent in the open arms of the elevated plus maze in mice. α-Androstenol protects against seizures induced by Pentylenetetrazole or electroshock with anxiolytic-like activity in mice[1][2][3].
Applications: Neuroscience-Neuromodulation
Formula: C19H30O
References: [1]Brooksbank BW, et al. The detection of 5alpha-androst-16-en-3alpha-ol in human male axillary sweat. Experientia. 1974 Aug 15;30(8):864-5./[2]Kaminski RM, et al. The pheromone androstenol (5 alpha-androst-16-en-3 alpha-ol) is a neurosteroid positive modulator of GABAA receptors. J Pharmacol Exp Ther. 2006 May;317(2):694-703. /[3]Starkenmann C, et al. 5α-Androst-16-en-3α-ol β-D-glucuronide, precursor of 5α-androst-16-en-3α-ol in human sweat. Chem Biodivers. 2013 Dec;10(12):2197-208.
CAS Number: 1153-51-1
Molecular Weight: 274.44
Research Area: Neurological Disease
Target: GABA Receptor
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