Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 6-chloro-N-[(1S)-1-(2-fluorophenyl)ethyl]-1-[5-O-[hydroxy(phosphonomethyl)phosphinyl]-ß-D-ribofuranosyl]-1H-pyrazolo[3,4-b]pyridin-4-amine
Purity: ≥95%
Formula Markup: C20H24ClFN4O9P2
Formula Weight: 580.824745
CAS Number: 2105904-82-1
Notes: AB-680 is an inhibitor of ecto-5'-nucleotidase, also known as CD73 (IC50 = 0.043 nM in CHO cells expressing the human enzyme).{72061} It is selective for ecto-5'-nucleotidase over nucleoside triphosphate diphosphorylase 1 (NTPDase 1), NTPDase 2, NTPDase 3, and NTPDase 8 (IC50s = >10 µM for all). AB-680 also inhibits ecto-5'-nucleotidase activity in isolated human and mouse CD8+ T cells and isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 0.008, 0.66, and 0.011 nM, respectively). It reverses AMP-induced decreases in the proliferation of, and IFN-γ and granzyme B secretion by, isolated human CD4+ and CD8+ T cells when used at a concentration of 200 nM.{72062} AB-680 (10 mg/kg) reduces tumor volume in a B16/F10 murine melanoma model alone and in combination with an antibody targeting programmed cell death protein 1 (PD-1).
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