Product Description: AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].
Applications: Cancer-programmed cell death
Formula: C20H24ClFN4O9P2
References: [1]Lawson KV, et al. Discovery and Characterization of AB680, a Potent and Selective Small-Molecule CD73 Inhibitor for Cancer Immunotherapy.
CAS Number: 2105904-82-1
Molecular Weight: 580.82
Compound Purity: 99.71
Research Area: Cancer
Solubility: DMSO : 200 mg/mL (ultrasonic)/H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C)
Target: CD73