Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[6-[5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl]-2-naphthalenyl]-methanesulfonamide
Purity: ≥98%
Formula Markup: C26H27N3O5S
Formula Weight: 493.5
CAS Number: 1132935-63-7
Notes: ABT-333 is an inhibitor of hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp; IC50s = 0.0022-0.0107 µM for genotypes 1a and 1b).{60958} It is selective for HCV genotype 1 polymerases over genotypes 2, 3, and 4 (IC50s = 0.9->20 µM), as well as human polymerases (IC50s = >100 µM). Formulations containning ABT-333, ombitasvir, paritaprevir, and ritonavir have been used in the treatment of HCV genotype 1 infections.