Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluoro-benzoic acid
Purity: ≥98%
Formula Markup: C15H17FN2O3
Formula Weight: 292.3
CAS Number: 1446711-81-4
Notes: Acoramidis is a kinetic stabilizer of transthyretin (TTR).{66856} It selectively binds to wild-type TTR and TTRV122I with negative cooperativity (Kd1s = 4.8 and 6.2 nM, respectively; Kd2s = 314 and 139 nM, respectively) over COX-1, COX-2, and the thyroid hormone nuclear receptor (IC50s = >10 µM for all). Acoramidis inhibits pH-induced amyloidogenesis of wild-type TTR and TTRV122I, indicating tetramer stabilization, when used at stoichiometric ratios of 1:1 and 1:0.5 with the number of TTR binding sites. It stabilizes TTRV122I in serum isolated from patients with familial amyloid cardiomyopathy when used at a concentration of 10 µM.
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