Target: Tau-441 (2N4R) P301S Mutant: ATTO 488
Nature: Recombinant
Swiss-Prot: P10636
Expression System: E. coli
Protein Length: Full Length
Amino Acid Sequence: MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHVSGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
Purification: Ion-exchange Purified
Purity: >95%
Storage Buffer: PBS pH7.4, 0.09% Azide
Protein Size: N/A
Conjugate: ATTO 488
Cellular Localization: Cytoplasm / Axolemma / Axolemma Plasma Membrane / Axon / Cell Body / Cell membrane / Cytoplasmic Ribonucleoprotein Granule / Cytoplasmic Side / Cytoskeleton / Cytosol / Dendrite / Growth cone / Microtubule / Microtubule Associated Complex / Neurofibrillary Tangle / Neuronal Cell Body / Nuclear Periphery / Nuclear Speck / Nucleus / Peripheral membrane protein / Plasma Membrane / Tubulin Complex
Scientific Background: Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). 2N4R, or Tau-441 is the full length tau protein. P301S is a mutation encoded by exon 10 (4) that impairs the ability of tau to assemble microtubules (5).
References: 1. www.alz.org/alzheimers-dementia/facts-figures2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146–148 (1907)3. Matsumoto, G. et al. (2018). Int J Mol Sci. 19, 1497.4. Goedert, M. and Spillantini, M. G. (2017). Mol Brain. 10:18.5. Bugiani, O. et al. (1999). J Neuropathol Exp Neurol. 58(6):667-77.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Deutsch
English
