Activin RIB/ALK-4, Mouse (HEK293, Fc)

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Product Description: Activin RIB, also known as activin receptor type-1B (ACVR1B) or ALK-4, is a type I transmembrane serine/threonine kinase receptor that is part of the TGF-β receptor superfamily. Activin binds to a type II activin receptor (ACVR2or ACVR2B) and then recruits ACVR1B[1][2][3]. Activin RIB/ALK-4 Protein, Mouse (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 95 amino acids (L32-E126).

Formula: 11479(Gene_ID)Q61271 (L32-E126)(Accession)

References: [1]Chizu Mukasa, et al. Activin Signaling Through Type IB Activin Receptor Stimulates Aromatase Activity in the Ovarian Granulosa Cell-Like Human Granulosa (KGN) Cells. Endocrinology. 2003 Apr;144(4):1603-11./[2]Z Gu, et al. The Type I Activin Receptor ActRIB Is Required for Egg Cylinder Organization and Gastrulation in the Mouse. Genes Dev. 1998 Mar 15;12(6):844-57./[3]Dev Dyn, et al. Developmental analysis of activin-like kinase receptor-4 (ALK4) expression in Xenopus laevis. . 2005 Feb;232(2):393-8./[4]Qian Wang, et al. Activin Receptor-Like Kinase 4 Haplodeficiency Mitigates Arrhythmogenic Atrial Remodeling and Vulnerability to Atrial Fibrillation in Cardiac Pathological Hypertrophy. J Am Heart Assoc. 2018 Aug 21;7(16):e008842./[5]Wanglong Qiu, et al. Conditional activin receptor type 1B (Acvr1b) knockout mice reveal hair loss abnormality. J Invest Dermatol. 2011 May;131(5):1067-76./[6]G H Su, et al. ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3254-7./[7]Kamil Matulka, et al. PTP1B is an effector of activin signaling and regulates neural specification of embryonic stem cells. Cell Stem Cell. 2013 Dec 5;13(6):706-19.

Molecular Weight: 39-50 kDa

Compound Purity: 98.0

• Artikelnummer: MEXHY-P7486-50UG
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P7486-50UG
• Verpackungseinheit: 50 μg
• Mengeneinheit: STK