ACU 4429 (hydrochloride), CAS 1141934-97-5

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: (aR)-a-(2-aminoethyl)-3-(cyclohexylmethoxy)-benzenemethanol, monohydrochloride

Purity: ≥95%

Formula Markup: C16H25NO2 / HCl

Formula Weight: 299.83588

CAS Number: 1141934-97-5

Notes: ACU 4429 is an inhibitor of retinal pigment epithelium 65 (RPE65; IC50 = 4.4 nM), an enzyme that catalyzes the isomerization of 11-trans retinol to 11-cis retinol (Item No. 33207) in the visual cycle.{58360} It reduces rod photoreceptor recovery in dark-adapted mice after photobleaching (ED50 = 0.21mg/kg) and reversibly decreases the regeneration of 11-cis retinal oxime in the same model (ED50 = 0.18 mg/kg). ACU 4429 also prevents light-induced photoreceptor cell loss in dark-adapted albino mice. It reduces lipofuscin autofluorescence and decreases the level of retinoid toxin (A2E) in the RPE in an Abca4-/- mouse model of Stargardt disease (ED50 = 0.47 mg/kg).

• Artikelnummer: CAY33242-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33242-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK