Adefovir dipivoxil, CAS 142340-99-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2,2-dimethyl-propanoic acid, 1,1'-[[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]phosphinylidene]bis(oxymethylene)] ester

Purity: ≥98%

Formula Markup: C20H32N5O8P

Formula Weight: 501.470741

CAS Number: 142340-99-6

Notes: Adefovir dipivoxil is a prodrug form of the antiviral nucleoside analog adefovir (Item No. 18650).{45446} Adefovir dipivoxil inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 2.2.15 cells infected with HBV (EC50 = 0.517 μM).{45447} It is cytotoxic to HepG2 2.2.15 cells with a 50% cytotoxicity concentration (CC50) value of 540 μM. Adefovir dipivoxil inhibits HBV replication in the liver of HBV transgenic mice (ED50 = 0.2 μmol/kg per day).{45448} Formulations containing adefovir dipivoxil have been used in the treatment of chronic HBV infection.

• Artikelnummer: CAY28373-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28373-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK