Adenylosuccinic Acid, CAS 19046-78-7

Adenylosuccinic Acid, CAS 19046-78-7
Artikelnummer
CAY29696-10
Verpackungseinheit
10 mg
Hersteller
Cayman Chemical

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Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[9-(5-O-phosphono-ß-D-ribofuranosyl)-9H-purin-6-yl]-L-aspartic acid

Purity: ≥95%

Formula Markup: C14H18N5O11P

Formula Weight: 463.3

CAS Number: 19046-78-7

Notes: Adenylosuccinic acid is a purine nucleotide and an intermediate in the purine nucleotide cycle.{52338} It is converted into adenosine 5'-monophosphate (AMP; Item No. 21094) and fumarate by adenylosuccinate lyase (ADSL) in the cytosol. Adenylosuccinic acid (10 µM) inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay.{52339} It induces contractions in isolated guinea pig uterus strips, which express adenosine receptors, when used at a concentration of 100 µM.{52341} Adenylosuccinic acid (10 µM) increases glucose-induced insulin exocytosis in INS-1 832/13 insulinoma cells.{52340} In vivo, adenylosuccinic acid (3,000 µg/ml in the drinking water) decreases muscle damage and pseudohypertrophy in a dystrophin-deficient mdx mouse model of Duchenne muscular dystrophy (DMD).{51595} Urine levels of adenylosuccinic acid are increased in patients with ADSL deficiency, an inborn error of metabolism characterized by various neurological symptoms, including intellectual disability and seizures, as well as respiratory failure.{51594}
Mehr Informationen
Artikelnummer CAY29696-10
Hersteller Cayman Chemical
Hersteller Artikelnummer 29696-10
Verpackungseinheit 10 mg
Mengeneinheit STK
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