ADX88178, CAS 1235318-89-4

Product Description: ADX88178 is a potent metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 4 nM for human mGluR4.

Applications: Neuroscience-Neuromodulation

Formula: C12H12N6S

References: [1]Fujinaga M, et al. Radiosynthesis and evaluation of 5-methyl-N-(4-[(11)C]methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine ([(11)C]ADX88178) as a novel radioligand for imaging of metabotropic glutamate receptor subtype 4 (mGluR4). Bioorg Med Chem Lett. 2016 Jan 15;26(2):370-4./[2]Ponnazhagan R, et al. The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia. J Neuroimmune Pharmacol. 2016 Jun;11(2):231-7./[3]Kalinichev M, et al. Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders. J Pharmacol Exp Ther. 2014 Sep;350(3):495-505.

CAS Number: 1235318-89-4

Molecular Weight: 272.33

Compound Purity: 99.69

Research Area: Neurological Disease

Solubility: DMSO : 16.67 mg/mL (ultrasonic)

Target: mGluR

• Artikelnummer: MEXHY-18654-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-18654-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK