Afatinib-d6, CAS 1313874-96-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: (2E)-N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-[di(methyl-d3)amino]-2-butenamide

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C24H19ClD6FN5O3

Formula Weight: 492.0

CAS Number: 1313874-96-2

Notes: Afatinib-d6 is intended for use as an internal standard for the quantification of afatinib (Item Nos. 21567 / 11492) by GC- or LC-MS. Afatinib is an irreversible inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 (IC50s = 0.5 and 14 nM, respectively).{33871} It increases the cytotoxicity of adriamycin in a concentration-dependent manner in multidrug-resistant A549T lung cancer cells overexpressing P-glycoprotein.{42401} Afatinib (20 mg/kg) reduces tumor growth in ErbB2-amplified NCI-N87 and NUGC4 gastric cancer mouse xenograft models.{42402} Formulations containing afatinib have been used in the treatment of non-small cell lung cancer.

• Artikelnummer: CAY22552-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22552-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung