Afizagabar, CAS 1398496-82-6

Product Description: Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy[1].

Applications: Neuroscience-Neuromodulation

Formula: C19H12FN3O2S

References: [1]Etherington LA, et al. Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent. Neuropharmacology. 2017;125:353-364.

CAS Number: 1398496-82-6

Molecular Weight: 365.38

Compound Purity: 98.40

Research Area: Neurological Disease

Solubility: DMSO : 6.25 mg/mL (ultrasonic)

Target: GABA Receptor

• Artikelnummer: MEXHY-120051-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-120051-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK