Shelf life (days): 1460.0
Formulation: A film
Formal Name: (aR,?S)-?-[(3-carboxy-1-oxopropyl-2,2,3,3-d4)amino]-a-methyl-[1,1'-biphenyl]-4-pentanoic acid, a-ethyl ester
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C24H25D4NO5
Formula Weight: 415.51504
CAS Number: 1884269-07-1
Notes: AHU377-d4 is intended for use as an internal standard for the quantification of AHU377 (Item Nos. 36230 / 21473) by GC- or LC-MS. AHU377 is an ethyl ester prodrug form of the neprilysin inhibitor LBQ657 (Item No. 19829).{42277} It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used in the treatment of mild to moderate hypertension and chronic heart failure.
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