AIM-100, CAS 873305-35-2

Product Description: AIM-100 is a potent and selective Ack1 inhibitor with an IC50 of 21.58 nM. AIM-100 also inhibits Tyr267 phosphorylation. AIM-100 does not inhibits other kinases including PI3-kinase and AKT subfamily members. AIM-100 has an anticancer effect[1][2].

Applications: Cancer-Kinase/protease

Formula: C23H21N3O2

References: [1]Mahajan K, et al. Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Am J Pathol. 2012 Apr;180(4):1386-93./[2]Mahajan K, et al. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. J Biol Chem. 2012 Jun 22;287(26):22112-22./[3]Mahajan K, et al. Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. Prostate. 2010 Sep 1;70(12):1274-85.

CAS Number: 873305-35-2

Molecular Weight: 371.43

Compound Purity: 99.95

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Ack1

• Artikelnummer: MEXHY-15290-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15290-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK