Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide
Purity: ≥95%
Formula Markup: C19H21BrN2O3S
Formula Weight: 437.4
CAS Number: 420831-40-9
Notes: The sirtuin SIRT2 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates.{21799} It has roles in metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases, potentially including Alzheimer’s, Huntington’s, and Parkinson’s diseases.{21799,21800,21803} AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM).{21802} In culture, it diminishes neuronal cell death induced by mutant huntingtin fragment.{21802} In addition, AK-7 down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo.{21802}
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