GDF-15, Human (P.pastoris, His)

Don’t miss this promotion: enjoy a 20% discount on all recombinant proteins for our supplier MedChem Express until December 31, 2025. These special prices are already discounted – no additional discounts can be applied during the promotion period.

Product Description: Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-β (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCγ)[1]. GDF-15 Protein, Human (P.pastoris, His) has 112 amino acids expressed by P.pastoris yeast cells with N-terminal His tag.

Formula: 9518(Gene_ID)Q99988 (A197-I308)(Accession)

References: [1]Assadi A, et al. GDF15, an update of the physiological and pathological roles it plays: a review. Pflugers Arch. 2020 Nov;472(11):1535-1546./[2]Artz A, et al. GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-βRII heterodimer. Blood. 2016 Jul 28;128(4):529-41.

Molecular Weight: Approximately 18.2 kDa

Compound Purity: 97.00

• Artikelnummer: MEXHY-P75170-20UG
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P75170-20UG
• Verpackungseinheit: 20 μg
• Mengeneinheit: STK