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Protein Tag: N-His
Uniprot: Q60994
Accession: Q60994-1
Background: Adiponectin (AdipoQ),an adipocyte-derived hormone,is one of the most abundant adipokines in the blood circulation. Adiponectin modulates a number of metabolic processes,including improving insulin sensitivity and anti-inflammatory activity. The role of AdipoQ in reproduction is not yet fully understood,but the expression of AdipoQ in reproductive tissues has been observed in various animals and humans,including chicken testis,bovine ovary,and human placenta. Adiponectin exerts its effects by activating a range of different signaling molecules via binding to two transmembrane AdipoQ receptors,AdipoR1 and AdipoR2. AdipoR1 is expressed primarily in the skeletal muscle,whereas AdipoR2 is predominantly expressed in the liver. AdipoQ May play a role in cell growth,angiogenesis and tissue remodeling by binding and sequestering various growth factors.
Bio Acitivity: Not validated for activity
Sequence: Glu18-Asn247
Purity: > 85% as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Endotoxin: < 10 EU/mg of the protein as determined by the LAL method.
Calculated MW: 24.9 kDa
Observed MW: 27.22 kDa
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