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Protein Tag: C-His
Uniprot: Q9NZQ7
Accession: Q9NZQ7
Background: Programmed cell death ligand 1(CD274,or B7-H1,PD-L1),is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with an their CD28 family receptors,the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell,and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal,essential for T-cell proliferation and production of IL10 and IFNG,in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with an a calculated molecular weight of 33 kDa,the apparent molecular weight has been reported as 45-70 kDa,suggesting probable glycosylation .
Bio Acitivity: Not validated for activity
Sequence: Met1-Thr239
Purity: > 90% as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Endotoxin: < 1.0 EU/mg of the protein as determined by the LAL method.
Calculated MW: 26.1 kDa
Observed MW: 35-40 kDa
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