Recombinant Human GITR/TNFRSF18 Protein(Fc Tag)

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Protein Tag: C-Fc

Uniprot: Q9Y5U5

Accession: Q9Y5U5

Background: GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.

Bio Acitivity: Not validated for activity

Sequence: Gln26-Glu161

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin: < 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW: 39.9 kDa

Observed MW: 45 kDa

• Artikelnummer: ELSPDMH100336-1
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: PDMH100336-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK