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Protein Tag: C-Fc
Uniprot: P21583
Accession: P21583
Background: Similar to Kit ligand precursor (C-kit ligand) , also known as Stem cell factor (SCF) , Mast cell growth factor (MGF) , or Hematopoietic growth factor KL. SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development , and hematopoiesis , all believed to reflect a role in cell migration. In adults , it functions pleiotropically , while mostly noted for its continued requirement in hematopoiesis. SCF/C-kit ligand stimulates the proliferation of mast cells. This protein can augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. It may act synergistically with other cytokines , probably interleukins SCF/C-kit ligand is the ligand for the tyrosine kinase receptor c-kit , which is expressed on both primitive and mature hematopoietic progenitor cells. In vitro , SCF/C-kit ligand synergizes with other growth factors , such as granulocyte colony-stimulating factor (G-CSF) , granulocyte-macrophage colony-stimulating factor , and interleukin-3 to stimulate the proliferation and differentiation of cells of the lymphoid , myeloid , erythroid , and megakaryocytic lineages. In vivo , SCF/C-kit also synergizes with other growth factors and has been shown to enhance the mobilization of peripheral blood progenitor cells in combination with G-CSF. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two-to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.
Bio Acitivity: Not validated for activity
Sequence: Glu26-Ala190
Purity: > 90% as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Endotoxin: < 1.0 EU/mg of the protein as determined by the LAL method.
Calculated MW: 43.0 kDa
Observed MW: 50 kDa
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