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Protein Tag: C-His
Uniprot: Q02763
Accession: Q02763
Background: TEK , or TIE-2 , is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE , and these two receptors play critical roles in vascular maturation , maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand , Angiopoietin-1 , result in embryonic lethality , demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.
Bio Acitivity: Not validated for activity
Sequence: Ala23-Leu748
Purity: > 90% as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Endotoxin: < 1.0 EU/mg of the protein as determined by the LAL method.
Calculated MW: 104.7 kDa
Observed MW: 105 kDa
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