Recombinant Mouse Agrp Protein(GST Tag)

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Protein Tag: N-GST

Uniprot: P56473

Accession: P56473

Background: Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.

Bio Acitivity: Not validated for activity

Sequence: Val21-Thr131

Purity: > 85% as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

Endotoxin: < 10 EU/mg of the protein as determined by the LAL method

Calculated MW: 38.1 kDa

Observed MW: 38 kDa

• Artikelnummer: ELSPDEM100324-1
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: PDEM100324-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK