Recombinant Mouse APRIL/TNFSF13 Protein(Fc Tag)

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Protein Tag: C-Fc

Uniprot: Q9D777

Accession: Q9D777

Background: TNFSF13 is a member of the tumor necrosis factor (TNF) ligand family. It is a ligand for TNFRSF17/BCMA. TNFSF13 is lowly expressed in normal tissues, but is elevated in several types of tumors and transformed cell lines. It is important for B cell development. TNFSF13 may also play a role in T-independent type II antigen responses and T cell survival, and induce proliferation/survival of non lymphoid cells. It exists as a functional homotrimer. It can bind to two cell surface receptors, BCMA and TACI, which it shares with BAFF to exert downstream T-and B-cell regulatory effects. TNFSF13 also has been demonstrated to bind to proteoglycans on the cell surface.

Bio Acitivity: Not validated for activity

Sequence: Ala96-Leu241

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin: < 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW: 40.9 kDa

Observed MW: 42 kDa

• Artikelnummer: ELSPDMM100178-500
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: PDMM100178-500
• Verpackungseinheit: 500μg
• Mengeneinheit: STK