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Protein Tag: C-Fc
Uniprot: P32972
Accession: P32972
Background: CD30 ligand (CD30L) , also known as CD153 and TNFSF8 , is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily , and is a specific ligand for CD30/TNFRSF8 originally described as a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. CD30L is a type-II membrane glycoprotein expressed on activated T cells , stimulated monocyte-macrophages , granulocytes , eosinophils , and some Burkitt-like lymphoma cell lines. CD30L is capable of transducing signals through CD30 on different CD30+ lymphoma cell lines , and mediates pleiotropic biologic effects including cell proliferation , activation , differentiation , as well as cell death by apoptosis. CD30-CD30 ligand interaction has been suggested to have a pathophysiologic role in malignant lymphomas , particularly Hodgkin disease , large cell anaplastic lymphomas and Burkitt lymphomas , and is also involved in activation and functioning of the T cell-dependent immune response. Thus , CD153 and its receptor CD30 are regarded as therapeutic targets in hematologic malignancies , autoimmune and inflammatory diseases.全称
Bio Acitivity: Not validated for activity
Sequence: Gln68-Asp239
Purity: > 90% as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Endotoxin: < 1.0 EU/mg of the protein as determined by the LAL method.
Calculated MW: 43.8 kDa
Observed MW: 55-65 kDa
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