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Protein Tag: C-Fc
Uniprot: P29699
Accession: P29699
Background: Fetuin-A , also known as Alpha-2-HS-Glycoprotein (AHSG) , belongs to the Fetuin family , is a plasma binding protein , and is more abundant in fetal than adult blood. It is involved in several functions , such as endocytosis , brain development and the formation of bone tissue. Fetuins are carrier proteins like albumin. Fetuin-A forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus Fetuin-A is a potent inhibitor of pathological calcification. The circulating levels of fetuin-A , a well-described inhibitor of calcification , regulate the cell-dependent process of osteogenesis. The low circulating fetuin-A levels are associated with a greater prevalence and/or severity of Vascular calcification (VC) and increased risk for all-cause and cardiovascular mortality. However , high circulating fetuin-A levels appear to induce insulin resistance and , in non-dialyzed subjects with diabetic nephropathy , are directly related to VC burden. The emerging role of fetuin-A deficiency as a risk factor in dialysis patients was documented in cross-sectional studies demonstrating a significant correlation with all-cause and cardiovascular mortality. Additionally , Human fetuin-A is a negative acute phase protein involved in inflammatory diseases , thus being a potential physiological regulator of meprin activity. Fetuin-A is a broad-range protease inhibitor. Fetuin-A and cystatin C as endogenous proteolytic regulators of meprin activity broadens our understanding of the proteolytic network in plasma.
Bio Acitivity: Not validated for activity
Sequence: Ala19-Ile345
Purity: > 90% as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Endotoxin: < 1.0 EU/mg of the protein as determined by the LAL method.
Calculated MW: 57.6 kDa
Observed MW: 70-80 kDa
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