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Protein Tag: N-His
Uniprot: Q61686
Accession: Q61686
Background: Component of heterochromatin that recognizes and binds histone H3 tails methylated at "Lys-9" (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when "Tyr-41" of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Bio Acitivity: Not validated for activity
Sequence: Met 1-Ser 191
Purity: > 95% as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Endotoxin: < 10 EU/mg of the protein as determined by the LAL method.
Calculated MW: 20.9 kDa
Observed MW: 25 kDa
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