Aliskiren (hemifumarate), CAS 173334-58-2

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: (aS,?S,dS,?S)-d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-?-hydroxy-4-methoxy-3-(3-methoxypropoxy)-a,?-bis(1-methylethyl)-benzeneoctanamide, 2E-butenedioate

Purity: ≥95%

Formula Markup: C30H53N3O6 / 1/2C4H4O4

Formula Weight: 609.8

CAS Number: 173334-58-2

Notes: Aliskiren is a nonpeptide inhibitor of renin (IC50 = 0.6 nM for the human enzyme).{31535} Aliskiren (10 and 30 mg/kg per day) reduces blood pressure and prevents albuminuria in renin-overexpressing TG(mRen-2)27 rats in a model of streptozotocin-induced diabetes.{61205} It also reduces cardiac hypertrophy and fibrosis induced by heart pressure overload in mice.{61206} Formulations containing aliskiren have been used in the treatment of hypertension.

• Artikelnummer: CAY19640-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 19640-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK