Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[4-[[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]oxy]-2,5-difluorophenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
Purity: ≥98%
Formula Markup: C26H21F3N4O4
Formula Weight: 510.5
CAS Number: 1345847-93-9
Notes: Altiratinib is a multiple kinase inhibitor, blocking Met, Tie2, VEGF2, TrkA, TrkB, and TrkC with IC50 values of 2.7, 8.0, 9.2, 0.85, 4.6, and 0.83 nM, respectively.{32781} It also inhibits several mutant Met isoforms at nanomolar concentrations. Altiratinib inhibits the proliferation of several cancer cell lines in vitro and blocks capillary tube formation by HMVEC cells.{32781} It is orally bioavailable and penetrates the blood brain barrier, suppressing the growth of subcutaneous and intracerebroventricular xenograft tumors in mice.{32781,32780}
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