ALV1, CAS 2438124-79-7

Product Description: ALV1 is a molecular glue degrader for Ikaros (IKZF1) and Helios (IKZF2), with DC50 values of 2.5 nM and 10.3 nM, respectively. ALV1 binds CRBN with an IC50 of 0.55 µM. ALV1 induces CRBN-Helios dimerization. ALV1 can be used to study the properties and functions of Treg cells[1].

Applications: COVID-19-anti-virus

Formula: C25H23ClN4O5

References: [1]Eric S Wang, et al. Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat Chem Biol. 2021 Jun;17(6):711-717.

CAS Number: 2438124-79-7

Molecular Weight: 494.93

Compound Purity: 96.88

Research Area: Cancer; Inflammation/Immunology

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: IKZF Family;Interleukin Related;Ligands for E3 Ligase;Molecular Glues

• Artikelnummer: MEXHY-145776-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-145776-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK