Product Description: Ammonium chloride-d4 is the deuterium labeled Ammonium chloride. Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor. Ammonium chloride is also a lysosome inhibitor[1][2][3].
Applications: Cancer-programmed cell death
Formula: ClD4N
References: [1]Huang X, et al. NH4Cl treatment prevents doxorubicin-induced myocardial dysfunction in vivo. Life Sci. 2019;227:94-100. /[2]Canning WM, Fields BN. Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells. Science. 1983;219(4587):987-988. /[3]Yu C,et al. Lysosome dysfunction enhances oxidative stress-induced apoptosis through ubiquitinated protein accumulation in Hela cells. Anat Rec (Hoboken). 2013 Jan;296(1):31-9.
CAS Number: 12015-14-4
Molecular Weight: 57.52
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Autophagy;Isotope-Labeled Compounds
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