Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (2S,5R,6R)-6-((R)-2-amino-2-(4-hydroxyphenyl-2,3,5,6-d4)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C16H15D4N3O5S
Formula Weight: 369.42952
CAS Number: 2673270-36-3
Notes: Amoxicillin-d4 is intended for use as an internal standard for the quantification of amoxicillin (Item No. 19188) by GC- or LC-MS. Amoxicillin is an orally bioavailable, semisynthetic β-lactam antibiotic.{42429} It inhibits the growth of 30 isolates of P. mirabilis and 89% of 30 E. coli strains when used at concentrations greater than or equal to 5 and 10 µg/ml, respectively, but resistance develops in strains of Klebsiella, Enterobacter, and indole-positive Proteus species.{31108} Amoxicillin is susceptible to bacterial β-lactamases but is active against β-lactamase-producing bacteria when used in combination with β-lactamase antibiotics such as clavulanic acid with MIC values of greater than 4,096 and 16 µg/ml without or with clavulanic acid, respectively, against 46 clinical isolates of β-lactamase-producing E. coli.{42429} Formulations containing amoxicillin have been used in the treatment of a variety of bacterial infections.
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