Target: Amyloid Fibrils (OC)
Conjugate: HRP
Product Type: Polyclonal
Immunogen: Fibrils prepared from human amyloid beta 42 peptide
Purification: Protein A Purified
Storage Buffer: 73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O
Specificity: Recognizes generic epitopes common to many amyloid fibrils and fibrillar oligomers, but not prefibrillar oligomers or natively folded proteins. Expected to detect in Mouse and Rat based on species homology.
Cellular Localization: Membrane
Scientific Background: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).
References: 1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547.2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366.3. Kayed R., et al. (2003) Science. 300(5618): 486-489.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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