Target Synonym: ANAPC2;APC2
Storage: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Background: A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation.
Buffer: PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Immunogen: A synthetic peptide of human ANAPC2
Dilution: WB 1:500-1:2000;IHC 1:50-1:200
Calculated MW: 93kDa
Observed MW: 102kDa
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