Tested Sample Types: Inhibitor
Assay Time: 50 min
Detection Type: Fluorometric method
Test Principle: Angiotensin Converting Enzyme 1(ACE1), also known as angiotensin converting enzyme (ACE), kininase II, and peptidy-carboxylpeptidase, is an important component of the renin-angiotensin system (RAS). In the RAS system, angiotensin is converted into angiotensin II. Angiotensin II can cause strong contractions of vascular smooth muscle, increasing peripheral vascular resistance and thereby leading to elevated blood pressure. Excessively high ACE1 activity can directly result in elevated blood pressure. ACE1 inhibitors can achieve the purpose of lowering blood pressure by inhibiting ACE1 activity.
The detection principle of this kit: ACE1 catalyzes the decomposition of the substrate, releasing fluorescent products. After adding the inhibitor, the generation of fluorescent substances will be inhibited, and the effect of the inhibitor is determined based on the degree of inhibition.
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