Product Description: Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system[1]. Anisomycin is a JNK activator, which increases phospho-JNK[2][3]. Anisomycin is a bacterial antibiotic[4].
Applications: Cancer-Kinase/protease
Formula: C14H19NO4
References: [1]Lu Z, et al. Colistin-induced autophagy and apoptosis involves the JNK-Bcl2-Bax signaling pathway and JNK-p53-ROS positive feedback loop in PC-12 cells./[2]Zhengle Tang, et al. In vivo toxicological evaluation of Anisomycin. Toxicol Lett. 2012 Jan 5;208(1):1-11./[3]Gao X, et al. Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIδ expression in the aged atrium. Cardiovasc Res. 2018 Apr 1;114(5):737-746./[4]Synthesis Marina Macías-Silva, et al. Anisomycin is a Multifunctional Drug: More than Just a Tool to Inhibit Protein. Current Chemical Biology, 2010, 4, 124-132.
CAS Number: 22862-76-6
Molecular Weight: 265.309
Compound Purity: 99.82
Research Area: Cancer; Infection
Solubility: DMSO : ≥ 50 mg/mL/H2O : 4 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Antibiotic;Apoptosis;Bacterial;DNA/RNA Synthesis;JNK;Parasite
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