CloneID: Ha5-1(5)2.1
Antigen Long Description: The original antibody was generated by immunizing of human γ2 producing XenoMice with RAT(E)-24P4C12 cells.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: This antibody specifically binds to recombinant 24P4C12 expressing cells (PC3-24P4C12) and multiple cancer cell lines expressing 24P4C12.
Application Notes (Clone): This antibody was capable of binding cells expressing 24P4C12 proteins on their surface in a flow cytometric assay. This antibody can be used in the development of an antibody-drug conjugate for targeted delivery of toxins to cancerous cells. The cytotoxicity of Ha5-1(5)2.1-vcMMAE antibody-drug conjugates was evaluated in PC3 cells engineered to express 24P4C12 and it was reported that it can selectively deliver a cytotoxic drug to 24P4C12 expressing cells leading to their killing. Ha5-1(5)2.1vcMMAE also inhibited the growth of subcutaneous and orthotopically established human androgen-independent prostate cancer xenograft in SCID mice (US8309093).
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