Anti-24P4C12 proteins (Ha5-1(5)2.1)

Anti-24P4C12 proteins [Ha5-1(5)2.1], Recombinant, IgG2b kappa, Mouse

CloneID: Ha5-1(5)2.1

Antigen Long Description: The original antibody was generated by immunizing of human γ2 producing XenoMice with RAT(E)-24P4C12 cells.

Buffer Composition: PBS only.

Specificity Statement: This antibody specifically binds to recombinant 24P4C12 expressing cells (PC3-24P4C12) and multiple cancer cell lines expressing 24P4C12.

Application Notes (Clone): This antibody was capable of binding cells expressing 24P4C12 proteins on their surface in a flow cytometric assay. This antibody can be used in the development of an antibody-drug conjugate for targeted delivery of toxins to cancerous cells. The cytotoxicity of Ha5-1(5)2.1-vcMMAE antibody-drug conjugates was evaluated in PC3 cells engineered to express 24P4C12 and it was reported that it can selectively deliver a cytotoxic drug to 24P4C12 expressing cells leading to their killing. Ha5-1(5)2.1vcMMAE also inhibited the growth of subcutaneous and orthotopically established human androgen-independent prostate cancer xenograft in SCID mice (US8309093).

• Artikelnummer: ABAAb04095-3.0-BT
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: Ab04095-3.0-BT
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Recombinant
• Methode: Flow Cytometry
• Isotyp: IgG2b kappa
• Wirt: Mouse