CloneID: G3-F11
Antigen Long Description: The original antibody was generated by immunizing mice with naked plasmid DNA containing N-terminal domain of encoding HAAH gene and recombinant HAAH polypeptide.
Origin Pub PMID: 21466288
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: Q12797
Specificity Statement: This antibody recognizes and binds human aspartyl/asparaginyl beta-hydroxylase. The human aspartyl (asparaginyl) beta-hydroxylase (HAAH) is an a-ketoglutarate-dependent dioxygenase, which is a membrane-associated and highly conserved enzyme that hydroxylates epidermal growth factor-like domains in transformation-associated proteins. Overexpression of HAAH is recognized as an indicator for carcinomas in humans.
Application Notes (Clone): The specificity and sensitivity of this antibody for human aspartyl (asparaginyl) beta-hydroxylase (HAAH) was determined using ELISA and western blot (PMID: 19663697). This antibody was also used in the identification of HAAH expression in seven tumor tissues, including hepatocellular carcinoma, lung cancer, kidney cancer, cholangiocarcinoma, prostate cancer, breast cancer, and glioblastoma by immunohistochemical stain (PMID: 19663697; 25394783).
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