CloneID: RCK103
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing a BALB/c mouse with a mix of cell preparations containing human cytokeratins.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P13647
Specificity Statement: The original antibody recognizes, among others, Cytokeratin 5. Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in Human epithelial tissues by at least 20 different polypeptides.
Application Notes (Clone): The antibody was employed for IHC staining of keratin in tumors and normal gland reserve cells (Vos et al., 1993; PMID: 8212457). Further, the antibody could stain the basal cell compartment in human prostate (Verhagen et al., 1992; PMID: 1384957). The antibody stained basal cells of the prostatic epithelium (Verhagen et al. 1988; PMID: 2458583).
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