CloneID: cAbTEM02
Antigen Long Description: The original antibody was generated by immunizing adult dromedary (Camelus dromedarius) with TEM-1 β-lactamase.
Origin Pub PMID: 11557473
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P62593
Specificity Statement: This antibody binds an enzyme called beta-lactamase produced by bacteria, which catalysis the breaking of the beta-lactam ring of beta-lactam antibiotics such as penicillin, cephalosporin, cephamycin and monobactam through hydrolysis. The breaking of the beta-lactam ring deactivates the antibacterial properties of the antibiotic molecule and provides antibiotic resistance in bacteria.
Application Notes (Clone): The binding reactivity of this antibody to TEM-1 beta-lactamase was determined using ELISA. This antibody was capable of inhibiting beta-lactamase activity in vitro with an IC50 of 0.035 μM (PMID: 11557473). This antibody binds TEM-1 (b-lactamase) with a binding affinity of 0.5 nM (PMID: 18262543).
Deutsch
English
