CloneID: A6.2
Antigen Long Description: The original antibody was raised by immunizing a A MNV-1-seropositive 129 mouse with brain homogenate containing MNV-1.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: Q2V8W4
Specificity Statement: This antibody is specific for the outermost tip of the closed conformation of the MNV-1 P2 domain.
Application Notes (Clone): The original antibody was used for an neutralization assay on the RAW 264.7 cells with the P-domain of MNV-1 (Taube et al., 2010; PMID:20335262). Further a plaque neutralization assay was performed on either MNV-1.CW1* or MNV-1CW1*.fab2 (Taube et al., 2010; PMID:20335262), on MNV-1 (Kolawole et al., 2014; PMID:24501415), and on MNV-1.CW1 or MNV-1 brain homogenate (Wobus et al., 2004; PMID:15562321). The structure of the original antibody was determined using cryo-EM (Taube et al., 2010; PMID:20335262). This antibody was used for an ELISA on CsCl-purified MNV-1 particles (Wobus et al., 2004; PMID:15562321).
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