CloneID: Mab6
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing Balb/C mice with CPV antigen.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted mouse IgG2a Fc Silent™ antibody, based on the original mouse IgG2a format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P17455; P04864
Specificity Statement: The antibody is specific for CPV and FPV. The antibody is specific for antigenic site A of CPV-2.
Application Notes (Clone): The original format of the antibody could neutralize CPV and FPV (Parrish et al., 1982; PMID: 6180709 and Nelson et al., 2007; PMID: 17217977). The specificity of the original format of the antibody was confirmed by ELISA analysis (Nelson et al., 2007; PMID: 17217977). The crystal structure of the Fab format of the antibody was determined by cry-electron microscopy (Hafenstein et al., 2009; PMID: 19321620).
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